The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level
نویسندگان
چکیده
منابع مشابه
Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis
The high rate of mortality in patients with sepsis results from an inappropriately amplified systemic inflammatory response to infection. Toll-like receptors (TLRs) are important for the activation of innate immunity against microbial pathogens. We demonstrate a critical role of TLR9 in the dysregulated immune response and death associated with sepsis. Compared with wild-type (WT) mice, TLR9(-/...
متن کاملAnalysis of Toll-like Receptor 9 Gene Polymorphisms in Sepsis.
AIM To analyze the effect of TLR-9 (-1486 T>C) and TLR-9 (C>T) gene polymorphisms both at TLR-9 levels and together with their sepsis parameters. In this regard, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used in order to detect TLR-9 gene polymorphisms, whereas the ELISA technique was used to analyze TLR-9 serum levels in 80 sepsis patients ...
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Mortality from sepsis has remained high despite recent advances in supportive and targeted therapies. Toll-like receptors (TLRs) sense bacterial products and stimulate pathogenic innate immune responses. Mice deficient in the common adapter protein MyD88, downstream from most TLRs, have reduced mortality and acute kidney injury (AKI) from polymicrobial sepsis. However, the identity of the TLR(s...
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ژورنال
عنوان ژورنال: In Vivo
سال: 2018
ISSN: 0258-851X,1791-7549
DOI: 10.21873/invivo.11428